In a new study a decreased survival was found in glioblastoma patients with long-term use of mobile and cordless phones. The study is free to download here.
According to the study use of wireless phones in the >20 years latency group (time since first use) yielded an increased hazard ratio (HR) = 1.7, 95% confidence interval (CI) = 1.2–2.3 for glioma, a decreased survival. For astrocytoma grade IV (glioblastoma multiforme; n = 926) mobile phone use yielded HR = 2.0, 95% CI = 1.4–2.9 and cordless phone use HR = 3.4, 95% CI = 1.04–11 in the same latency category. Due to the relationship with survival the classification of IARC (possibly carcinogenic to humans, Group 2B) is strengthened and RF-EMF should be regarded as human carcinogen requiring urgent revision of current exposure guidelines. The findings are discussed in detail in the article.
The p53 protein is a transcription factor that plays a vital role in regulating cell growth, DNA repair and apoptosis, and p53 mutations are involved in disease progression. In a recent study it was found that use of mobile phones for ≥3 hours a day was associated with increased risk for the mutant type of p53 gene expression in the peripheral zone of astrocytoma grade IV. The mutation was statistically significant correlated with shorter overall survival time. The study was rather small (n=63) and no data on latency of mobile phone use was given.
We have previously reported decreased survival in patients with glioblastoma multiforme associated with use of mobile phones. The present study supports our findings and gives insight into a possible genetic mechanism both for the increased risk for glioblastoma multiforme and the decreased survival.