The p53 protein is a transcription factor that plays a vital role in regulating cell growth, DNA repair and apoptosis, and p53 mutations are involved in disease progression. In a recent study it was found that use of mobile phones for ≥3 hours a day was associated with increased risk for the mutant type of p53 gene expression in the peripheral zone of astrocytoma grade IV. The mutation was statistically significant correlated with shorter overall survival time. The study was rather small (n=63) and no data on latency of mobile phone use was given.
We have previously reported decreased survival in patients with glioblastoma multiforme associated with use of mobile phones. The present study supports our findings and gives insight into a possible genetic mechanism both for the increased risk for glioblastoma multiforme and the decreased survival.