Radiofrequency radiation gives DNA damage in the NTP rat and mice study

The National Toxicology Program (NTP) animal study on cancer risk from exposure to radiofrequency radiation (RFR) has previously reported an increased incidence of glioma and Schwann cell tumors, that is similar types of tumors as have been reported in human epidemiology. We have commented on the similarity of the findings.

The NTP study presented recently data on DNA damage in the same study, see Smith-Roe SL et al. Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure. Environ Mol Mutagen. 2019 Oct 21. doi: 10.1002/em.22343.

Abstract

The National Toxicology Program tested two common radiofrequency radiation (RFR) modulations emitted by cellular telephones in a 2-year rodent cancer bioassay that included interim assessments of additional animals for genotoxicity endpoints. Male and female Hsd:Sprague Dawley SD rats and B6C3F1/N mice were exposed from gestation day 5 or postnatal day 35, respectively, to code division multiple access (CDMA) or global system for mobile (GSM) modulations over 18 h/day, at 10 min intervals, in reverberation chambers at specific absorption rates (SAR) of 1.5, 3, or 6 W/kg (rats, 900 MHz) or 2.5, 5, or 10 W/kg (mice, 1900 MHz). After 19 (rats) or 14 (mice) weeks of exposure, animals were examined for evidence of RFR-associated genotoxicity using two different measures. Using the alkaline (pH > 13) comet assay, DNA damage was assessed in cells from three brain regions, liver cells, and peripheral blood leukocytes; using the micronucleus assay, chromosomal damage was assessed in immature and mature peripheral blood erythrocytes. Results of the comet assay showed significant increases in DNA damage in the frontal cortex of male mice (both modulations), leukocytes of female mice (CDMA only), and hippocampus of male rats (CDMA only). Increases in DNA damage judged to be equivocal were observed in several other tissues of rats and mice. No significant increases in micronucleated red blood cells were observed in rats or mice. In conclusion, these results suggest that exposure to RFR is associated with an increase in DNA damage.

These results add to the evidence that RFR causes cancer. Increased risk is found in both human and animal studies with similarity of tumor types. The new NTP findings add mechanistic effects for carcinogenesis. RFR should be classified as a human carcinogen, Group 1.

Of interest is to compare these NTP exposures with results in the French Phonegate Alert report (https://www.phonegatealert.org/en) on SAR from use of mobile phones. As the table shows with 0 mm distance between the mobile phone and tissue (body contact) SAR values are much exceeding the limits and are actually in the range of those used in the NTP study. These SAR values are to be compared with the manufacture test keeping the phone at some distance from the body. This advice is usually not well informed about to the user but may be found in the instruction manual. This table shows the results presented by Dr Marc Arazi, International Public Symposium, Mainz, Germany, October 6,2019 (with courtesy).

www.phonegatealert.org

SAR comparison : 1gr and 10gr of tissue

 

Incorrect information about wireless phones and the risk for brain tumours in a Swedish newspaper

The well known Swedish daily newspaper, Svenska Dagbladet, has published an article that does not give correct information on the risk for brain tumours from use of wireless phones. The newspaper has refused to publish our rebuttal. It is now published in the medical journal, Medicinsk Access (only in Swedish).

Court rules on information on health risks from wireless phones

A court in Rome has judged that people must be informed on health risks from use of wireless phones, both mobile and cordless phones. The decision has not been appealed and the information campaign must start by July 16, 2019.

No doubt this is a victory for public health. Similar decision should be made in all countries. We have the knowledge of health risks but the population is not informed due to negligence by government and media like in Sweden. We have the scientific evidence on risks to human beings and also the environment by no action in undertaken. Instead, the 5th generation, 5G, of wireless communication is implemented without proper scientific studies on the risks (www.5gappeal.eu; www.emfcall.org).

More on the Italian verdict can be found here.

Environmental radiofrequency radiation at the Järntorget Square in Stockholm Old Town in Sweden compared with results on tumour risks in rats exposed to 1.8 GHz base station environmental emissions

We measured radiofrequency (RF) radiation at the Järntorget square in the Stockholm Old Town in a new study recently published.  In a previous study of the Old Town we found especially high RF radiation at that square. The maximum level in the present study was 11.6 V/m at the center of the square, where the antenna was focused. Järntorget’s mean value was 5.2 V/m, median 5.0 V/m, range 1.2-11.6 V/m.

Of interest is that this level can be compared to life-span carcinogenicity study on rats exposed to 1.8 GHz GSM environmental radiation performed at the Ramazzini Institute (RI) in Italy. A statistically significant increase in the incidence of malignant Schwannoma in the heart was found in male rats at the highest dose, 50 V/m. In treated female rats at the highest dose the incidence of malignant glial tumors was increased, although not statistically significant. In conclusion our study showed RF radiation levels at one square, Järntorget, in Sweden was only one order of magnitude lower than those showing increased incidence of tumours in the RI animal study. An increased cancer risk cannot be excluded for those working next to or at Järntorget for longer time periods.

These results indicate that it is pertinent to measure RF radiation levels in the environment and in homes. Such exposure levels should be declared for those intending to settle down in any dwelling.

The Public Health Agency of Sweden misleads about cancer risks from radiofrequency radiation

The mission of this Agency is according to their home page:

The Public Health Agency of Sweden has a national responsibility for public health issues and works to ensure good public health. The agency also works to ensure that the population is protected against communicable diseases and other health threats.

However, when it comes to radiofrequency radiation and health their report from 2017 gives a wrong evaluation of the state of knowledge. Cancer risks are denied. It was written by a former and a present member of ICNIRP so no doubt the message is not different from that provided by ICNIRP. Our critique is published only in Swedish but can be read here.

Fatal collision? Are wireless headsets a risk in treating patients?

In this recently published article wireless headsets are discussed. There is no open access to the article, but abstract is as follows:

Wireless-enabled headsets that connect to the internet can provide remote transcribing of patient examination notes. Audio and video can be captured and transmitted by wireless signals sent from the computer screen in the frame of the glasses. But using wireless glass-type devices can expose the user to a specific absorption rates (SAR) of 1.11–1.46 W/kg of radiofrequency radiation. That RF intensity is as high as or higher than RF emissions of some cell phones.  Prolonged use of cell phones used ipsilaterally at the head has been associated with statistically significant increased risk of glioma and acoustic neuroma. Using wireless glasses for extended periods to teach, to perform surgery, or conduct patient exams will expose the medical professional to similar RF exposures which may impair brain performance, cognition and judgment, concentration and attention and increase the risk for brain tumors. The quality of medical care may be compromised by extended use of wireless-embedded devices in health care settings. Both medical professionals and their patients should know the risks of such devices and have a choice about allowing their use during patient exams. Transmission of sensitive patient data over wireless networks may increase the risk of hacking and security breaches leading to losses of private patient medical and financial data that are strictly protected under HIPPA health information privacy laws.

A detailed discussion is made of such items as: What are wireless headsets and why are healthcare professionals being encouraged to use them? What is the problem for the medical professional? What is the problem for the patient? What’s the advice to medical professionals?

Increasing incidence of aggressive brain tumour (glioblastoma multiforme) in England during 1995-2015

A recent article describes increasing incidence of the most malignant type of brain tumor, glioblastoma multiforme (GBM) in England during 1995-2015. The number of patients increased from 2.4 to 5.0 per 100,000 during that time period. In total the yearly increase was from 983 to 2,531 patients, thus a substantial number. The incidence of low-grade glioma decreased but was stabilized from 2004, see figure 2. Thus the increasing incidence cannot be explained by low-grade glioma transforming to high-grade (GBM). The authors conclude that a general environmental factor must be the cause.

The increasing incidence is most pronounced for GBM in temporal or frontal parts of the brain, see figure 6. That is parts with highest exposure to radiofrequency radiation from the handheld wireless phone.

The increasing incidence of GBM was seen in all age groups but was most pronounced in those aged more than 55 years.

We published incidence data on brain tumours for the time period 1998-2015 based on the Swedish Cancer Register. In the age group 60-79 years the yearly incidence of high-grade glioma increased statistically significant in men with +1.68% (+0.39, +2.99 %) (n = 2,275) and in women with +1.38% (+0.32, +2.45%) (n = 1,585), see figures. Few patients were diagnosed in the age group 80+ yielding analysis less meaningful. High-grade glioma includes astrocytoma grades III and IV. Astrocytoma grade IV is the same as glioblastoma multiforme (GBM) with bad prognosis, survival about one year or less.

Our results are similar to those now published from England. All results are in agreement with wireless phones (mobile phones and cordless phones) causing glioma.