Radiofrequency radiation gives DNA damage in the NTP rat and mice study

The National Toxicology Program (NTP) animal study on cancer risk from exposure to radiofrequency radiation (RFR) has previously reported an increased incidence of glioma and Schwann cell tumors, that is similar types of tumors as have been reported in human epidemiology. We have commented on the similarity of the findings.

The NTP study presented recently data on DNA damage in the same study, see Smith-Roe SL et al. Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure. Environ Mol Mutagen. 2019 Oct 21. doi: 10.1002/em.22343.

Abstract

The National Toxicology Program tested two common radiofrequency radiation (RFR) modulations emitted by cellular telephones in a 2-year rodent cancer bioassay that included interim assessments of additional animals for genotoxicity endpoints. Male and female Hsd:Sprague Dawley SD rats and B6C3F1/N mice were exposed from gestation day 5 or postnatal day 35, respectively, to code division multiple access (CDMA) or global system for mobile (GSM) modulations over 18 h/day, at 10 min intervals, in reverberation chambers at specific absorption rates (SAR) of 1.5, 3, or 6 W/kg (rats, 900 MHz) or 2.5, 5, or 10 W/kg (mice, 1900 MHz). After 19 (rats) or 14 (mice) weeks of exposure, animals were examined for evidence of RFR-associated genotoxicity using two different measures. Using the alkaline (pH > 13) comet assay, DNA damage was assessed in cells from three brain regions, liver cells, and peripheral blood leukocytes; using the micronucleus assay, chromosomal damage was assessed in immature and mature peripheral blood erythrocytes. Results of the comet assay showed significant increases in DNA damage in the frontal cortex of male mice (both modulations), leukocytes of female mice (CDMA only), and hippocampus of male rats (CDMA only). Increases in DNA damage judged to be equivocal were observed in several other tissues of rats and mice. No significant increases in micronucleated red blood cells were observed in rats or mice. In conclusion, these results suggest that exposure to RFR is associated with an increase in DNA damage.

These results add to the evidence that RFR causes cancer. Increased risk is found in both human and animal studies with similarity of tumor types. The new NTP findings add mechanistic effects for carcinogenesis. RFR should be classified as a human carcinogen, Group 1.

Of interest is to compare these NTP exposures with results in the French Phonegate Alert report (https://www.phonegatealert.org/en) on SAR from use of mobile phones. As the table shows with 0 mm distance between the mobile phone and tissue (body contact) SAR values are much exceeding the limits and are actually in the range of those used in the NTP study. These SAR values are to be compared with the manufacture test keeping the phone at some distance from the body. This advice is usually not well informed about to the user but may be found in the instruction manual. This table shows the results presented by Dr Marc Arazi, International Public Symposium, Mainz, Germany, October 6,2019 (with courtesy).

www.phonegatealert.org

SAR comparison : 1gr and 10gr of tissue

 

Incorrect information about wireless phones and the risk for brain tumours in a Swedish newspaper

The well known Swedish daily newspaper, Svenska Dagbladet, has published an article that does not give correct information on the risk for brain tumours from use of wireless phones. The newspaper has refused to publish our rebuttal. It is now published in the medical journal, Medicinsk Access (only in Swedish).

Court rules on information on health risks from wireless phones

A court in Rome has judged that people must be informed on health risks from use of wireless phones, both mobile and cordless phones. The decision has not been appealed and the information campaign must start by July 16, 2019.

No doubt this is a victory for public health. Similar decision should be made in all countries. We have the knowledge of health risks but the population is not informed due to negligence by government and media like in Sweden. We have the scientific evidence on risks to human beings and also the environment by no action in undertaken. Instead, the 5th generation, 5G, of wireless communication is implemented without proper scientific studies on the risks (www.5gappeal.eu; www.emfcall.org).

More on the Italian verdict can be found here.

Environmental radiofrequency radiation at the Järntorget Square in Stockholm Old Town in Sweden compared with results on tumour risks in rats exposed to 1.8 GHz base station environmental emissions

We measured radiofrequency (RF) radiation at the Järntorget square in the Stockholm Old Town in a new study recently published.  In a previous study of the Old Town we found especially high RF radiation at that square. The maximum level in the present study was 11.6 V/m at the center of the square, where the antenna was focused. Järntorget’s mean value was 5.2 V/m, median 5.0 V/m, range 1.2-11.6 V/m.

Of interest is that this level can be compared to life-span carcinogenicity study on rats exposed to 1.8 GHz GSM environmental radiation performed at the Ramazzini Institute (RI) in Italy. A statistically significant increase in the incidence of malignant Schwannoma in the heart was found in male rats at the highest dose, 50 V/m. In treated female rats at the highest dose the incidence of malignant glial tumors was increased, although not statistically significant. In conclusion our study showed RF radiation levels at one square, Järntorget, in Sweden was only one order of magnitude lower than those showing increased incidence of tumours in the RI animal study. An increased cancer risk cannot be excluded for those working next to or at Järntorget for longer time periods.

These results indicate that it is pertinent to measure RF radiation levels in the environment and in homes. Such exposure levels should be declared for those intending to settle down in any dwelling.

The Public Health Agency of Sweden misleads about cancer risks from radiofrequency radiation

The mission of this Agency is according to their home page:

The Public Health Agency of Sweden has a national responsibility for public health issues and works to ensure good public health. The agency also works to ensure that the population is protected against communicable diseases and other health threats.

However, when it comes to radiofrequency radiation and health their report from 2017 gives a wrong evaluation of the state of knowledge. Cancer risks are denied. It was written by a former and a present member of ICNIRP so no doubt the message is not different from that provided by ICNIRP. Our critique is published only in Swedish but can be read here.

Fatal collision? Are wireless headsets a risk in treating patients?

In this recently published article wireless headsets are discussed. There is no open access to the article, but abstract is as follows:

Wireless-enabled headsets that connect to the internet can provide remote transcribing of patient examination notes. Audio and video can be captured and transmitted by wireless signals sent from the computer screen in the frame of the glasses. But using wireless glass-type devices can expose the user to a specific absorption rates (SAR) of 1.11–1.46 W/kg of radiofrequency radiation. That RF intensity is as high as or higher than RF emissions of some cell phones.  Prolonged use of cell phones used ipsilaterally at the head has been associated with statistically significant increased risk of glioma and acoustic neuroma. Using wireless glasses for extended periods to teach, to perform surgery, or conduct patient exams will expose the medical professional to similar RF exposures which may impair brain performance, cognition and judgment, concentration and attention and increase the risk for brain tumors. The quality of medical care may be compromised by extended use of wireless-embedded devices in health care settings. Both medical professionals and their patients should know the risks of such devices and have a choice about allowing their use during patient exams. Transmission of sensitive patient data over wireless networks may increase the risk of hacking and security breaches leading to losses of private patient medical and financial data that are strictly protected under HIPPA health information privacy laws.

A detailed discussion is made of such items as: What are wireless headsets and why are healthcare professionals being encouraged to use them? What is the problem for the medical professional? What is the problem for the patient? What’s the advice to medical professionals?

Increasing incidence of aggressive brain tumour (glioblastoma multiforme) in England during 1995-2015

A recent article describes increasing incidence of the most malignant type of brain tumor, glioblastoma multiforme (GBM) in England during 1995-2015. The number of patients increased from 2.4 to 5.0 per 100,000 during that time period. In total the yearly increase was from 983 to 2,531 patients, thus a substantial number. The incidence of low-grade glioma decreased but was stabilized from 2004, see figure 2. Thus the increasing incidence cannot be explained by low-grade glioma transforming to high-grade (GBM). The authors conclude that a general environmental factor must be the cause.

The increasing incidence is most pronounced for GBM in temporal or frontal parts of the brain, see figure 6. That is parts with highest exposure to radiofrequency radiation from the handheld wireless phone.

The increasing incidence of GBM was seen in all age groups but was most pronounced in those aged more than 55 years.

We published incidence data on brain tumours for the time period 1998-2015 based on the Swedish Cancer Register. In the age group 60-79 years the yearly incidence of high-grade glioma increased statistically significant in men with +1.68% (+0.39, +2.99 %) (n = 2,275) and in women with +1.38% (+0.32, +2.45%) (n = 1,585), see figures. Few patients were diagnosed in the age group 80+ yielding analysis less meaningful. High-grade glioma includes astrocytoma grades III and IV. Astrocytoma grade IV is the same as glioblastoma multiforme (GBM) with bad prognosis, survival about one year or less.

Our results are similar to those now published from England. All results are in agreement with wireless phones (mobile phones and cordless phones) causing glioma.

 

 

 

 

 

 

 

Increasing brain tumor rates in Sweden

Recently we published a new article on brain tumor rates in Sweden using the Inpatient Register for the time period 1998-2015. Also incidence data using the Swedish Cancer Register were analyzed for the same time period. The full article can be found here, see also abstract below.

We used the Swedish Inpatient Register (IPR) to analyze rates of brain tumors of unknown type (D43) during 1998-2015. Average Annual Percentage Change (AAPC) per 100,000 increased with +2.06%, 95% confidence interval (CI) +1.27, +2.86% in both genders combined. A joinpoint was found in 2007 with Annual Percentage Change (APC) 1998-2007 of +0.16%, 95% CI -0.94, +1.28%, and 2007-2015 of +4.24%, 95% CI +2.87, +5.63%. Highest AAPC was found in the age group 20-39 years. In the Swedish Cancer Register the age-standardized incidence rate per 100,000 increased for brain tumors, ICD-code 193.0, during 1998-2015 with AAPC in men +0.49%, 95% CI +0.05, +0.94%, and in women +0.33%, 95% CI -0.29, +0.45%. The cases with brain tumor of unknown type lack morphological examination. Brain tumor diagnosis was based on cytology/histopathology in 83% for men and in 87% for women in 1980 in the Cancer Register. This frequency increased to 90% in men and 88% in women in 2015. During the same time period CT and MRI imaging techniques were introduced and morphology is not always necessary for diagnosis. If all brain tumors based on clinical diagnosis with CT or MRI had been reported to the Cancer Register the frequency of diagnoses based on cytology/histology would have decreased in the register. The results indicate underreporting of brain tumor cases to the Cancer Register. The real incidence would be higher. Thus, incidence trends based on the Cancer Register should be used with caution. Use of wireless phones should be considered in relation to the change of incidence rates.

Case-control study on occupational exposure to extremely low-frequency electromagnetic fields and glioma risk

Exposure to extremely low-frequency electromagnetic fields (ELF-EMF) was in 2002 classified as a possible human carcinogen, Group 2B, by the International Agency for Research on Cancer (IARC) at WHO. In the international Interphone study on mobile phone use and glioma risk, glioma was associated with occupational ELF-EMF exposure in recent time windows. The authors concluded that such exposure may play a role in late stage carcinogenesis of glioma.

We assessed life time occupations in case-control studies during 1997-2003 and 2007-2009 on e.g. use of wireless phones and glioma risk. An ELF-EMF Job-Exposure Matrix was used for associating occupations with ELF exposure (μT). Cumulative exposure (μT-years), average exposure (μT), and maximum exposed job (μT) were calculated.

Cumulative exposure gave for astrocytoma grade IV (glioblastoma multiforme) in the time window 1-14 years before diagnosis odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.4-2.6, p linear trend <0.001, and in the time window 15+ years OR = 0.9, 95% CI = 0.6-1.3, p linear trend = 0.44 in the highest exposure categories 2.75+ and 6.59+ μT-years, respectively.

We concluded that we found an increased risk in late stage (promotion/progression) of astrocytoma grade IV for occupational ELF-EMF exposure. No statistically significant interaction was found between exposure to ELF-EMF and use of wireless phones (exposure to radiofrequency radiation; RF-EMF). They were independent risk factors for astrocytoma grade IV.

World Health Organization, radiofrequency radiation and health – a hard nut to crack (Review)

In a new article by Dr Lennart Hardell health effects from radiofrequency radiation, ICNIRP and the WHO agenda are discussed. The whole article can be found here, see also abstract below.

Abstract. In May 2011 the International Agency for Research on Cancer (IARC) evaluated cancer risks from radiofrequency (RF) radiation. Human epidemiological studies gave
evidence of increased risk for glioma and acoustic neuroma. RF radiation was classified as Group 2B, a possible human carcinogen. Further epidemiological, animal and mechanistic
studies have strengthened the association. In spite of this, in most countries little or nothing has been done to reduce exposure and educate people on health hazards from RF
radiation. On the contrary ambient levels have increased. In 2014 the WHO launched a draft of a Monograph on RF fields and health for public comments. It turned out that five
of the six members of the Core Group in charge of the draft are affiliated with International Commission on Non-Ionizing Radiation Protection (ICNIRP), an industry loyal NGO, and
thus have a serious conflict of interest. Just as by ICNIRP, evaluation of non-thermal biological effects from RF radiation are dismissed as scientific evidence of adverse health effects in the Monograph. This has provoked many comments sent to the WHO. However, at a meeting on March 3, 2017 at the WHO Geneva office it was stated that the WHO has no intention to change the Core Group.