Effects of radiofrequency exposure emitted from a GSM mobile phone on proliferation, differentiation, and apoptosis of neural stem cells

A recent article evaluated the effects of radiofrequency radiation emitted from a GSM 900-MHz mobile phone with different exposure duration on proliferation, differentiation and apoptosis of adult neural stem cells (NSCs) in vitro in mice.

Abstract: Due to the importance of neural stem cells (NSCs) in plasticity of the nervous system and treating neurodegenerative diseases, the main goal of this study was to evaluate the effects of radiofrequency radiation emitted from a GSM 900-MHz mobile phone with different exposure duration on proliferation, differentiation and apoptosis of adult murine NSCs in vitro. We used neurosphere assay to evaluate NSCs proliferation, and immunofluorescence assay of neural cell markers to examine NSCs differentiation. We also employed alamarBlue and caspase 3 apoptosis assays to assess harmful effects of mobile phone on NSCs. Our results showed that the number and size of resulting neurospheres and also the percentage of cells differentiated into neurons decreased significantly with increasing exposure duration to GSM 900-MHz radiofrequency (RF)-electromagnetic field (EMF). In contrast, exposure to GSM 900-MHz RF-EMF at different durations did not influence cell viability and apoptosis of NSCs and also their astrocytic differentiation. It is concluded that accumulating dose of GSM 900-MHz RF-EMF might have devastating effects on NSCs proliferation and neurogenesis requiring more causations in terms of using mobile devices.

One of the authors, SMJ Mortazavi, made the following summary of the results:

  1. Exposure to GSM 900 MHz mobile phone radiofrequency electromagnetic fields (RF-EMF) decreases the proliferation of neural stem cells (NSCs).
  2. Decreased neuronal differentiation in NSCs was also observed in cells exposed to RF-EMF.
  3. Exposure to GSM 900 MHz RF-EMF did not influence the viability and apoptosis of NSCs.
  4. Active neurogenesis from the stem cells occurs during the first trimester of pregnancy, which could possibly get affected by accumulating dose of exposure to mobile phone RF-EMF.
  5. Further research is needed to verify if exposure to mobile phone RF-EMF during the first trimester of pregnancy is associated with increased susceptibility to disorders such as attention deficit hyperactivity disorder (ADHD) or autism in the offspring.

Comment: These results are on mice but are anyhow of interest and add to the evidence that maternal use of mobile phone during pregnancy may increase the risk of child behavioral problems, see blog July 11, 2017.

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